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After 48 hours, increased activation and proliferation was observed as well as mRNA upregulation of proinflammatory markers expressed by microglia exposed to degenerated IVDs, compared to microglia exposed to unloaded controls

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Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt