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Description

10.1002/(SICI)1096-9896(200004)190:5 3.0.CO;2-9

This progress remarkably extends the diseases that can be treated by RNAi therapeutics

This calculation assumed intra-subject coefficients of variation of approximately 12% for AUC and 17% for C max , based on earlier studies with the FD formulation and values between 0.95 and 1.05 for the true treatment ratio test/reference

Treatment of DIO mice with PYYMK-801 and GIPMK-801 did not affect body weight or food intake beyond that of the parent peptide analogues (Extended Data Fig