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For a subcutaneous injection, the needle is inserted at a 45-degree angle so that it pierces the skin but does not reach the muscle tissue

We implemented the SQ infusion of OHCbl using a SQ catheter system together with a small, portable pump in four patients with cobalamin-related remethylation disorders in whom frequent IM injections were not or no longer feasible

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Expert clinicians emphasize the importance of having clear goals and practical support

Subsequent interest in AOD-9604 has been limited to niche research areas, particularly osteoarthritis, where intra-articular injection might bypass systemic bioavailability limitations