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For example, in glutathione peroxidase (GPx), the selenol group (SeH) of selenocysteine is oxidized by peroxides to selenenic acid (SeOH), which is then reduced back to the selenol form by glutathione, completing the catalytic cycle

We observed that ITP exhibits a similar effect to insulin in inducing FRET signal changes associated with IR, suggesting that the conformational changes in IR induced by ITP may be analogous to those induced by insulin (Fig