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Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation

Chen X, Zhang P, Zhang H, Ma X, Zhang Y, Wu Y, et al

5 Pharmacological PRMT5/MAT2A inhibition and selectivity for MTAP-deficient cells A limiting factor to targeting PRMT5 directly is its important role in normal tissue function, but a synthetically lethal interaction with an MTAP -negative background should, in principle, provide a suitable therapeutic window