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Neurol 2014;75:837850

If tremors exist or body movement is greatly affected, a referral may be given to a neurologist to rule out neurodegenerative diseases such as Parkinson's Disease

Some specific types of medication (like those that include nitrates) can lead to adverse reactions when taking nitric oxide supplements, such as an unsafe drop in blood pressure

Additional cellular studies using mouse hippocampal HT-22 cells exposed to A1-42 oligomers have demonstrated that copper overload can promote A-induced neuronal damage via the NLRP3/caspase-1/Gasdermin D pathway (179,194)

The most beneficial therapeutic approach to treating uncontrolled painful DPN that does not respond to monotherapy is combination therapy, 8% capsaicin patch, or SCS