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Gladman D, Nash P, Goto H, Birt J, Lin C-Y, Orbai A-M, et al

10.1016/j.bbrc.2011.08.007 Biochem

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For example, it is not known whether the complications related to anemia are simply due to a decrease in the number/concentration of circulating RBCs (inducing a systemic dysfunction of normal RBCs) or are rather due to an intrinsic RBC dysfunction ( e.g ., less efficient redox buffering, decreased NO production, increased RBC fragility) or both

Studies have looked into their effects through clinical trials and detailed analyses