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(2002) Curr Opin Clin Nutr Metab Care 5:321-326

doi: 10.1111/1750-3841.15598 491 YangRShanSZhangCShiJLiHLiZ

Research shows that nicotine activates nAChRs on dopaminergic neurons, which are crucial for regulating neurotransmitter release and neuronal excitability (Quik et al., 2008)

Despite their proliferative arrest, senescent cells exhibit a metabolically active state characterized by an altered glycolytic flux, perturbed lipid homeostasis, mitochondrial dysfunction, and a disrupted nicotinamide adenine dinucleotide (NAD +) redox balance, all of which contribute to vascular damage