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For instance, metformin mitigates testicular damage caused by diabetes by reducing apoptosis and inducing autophagy through the PK2/PKR/AKT/GSK3 signaling pathway [30]

Similar effects have been observed in other animal models

217 Astrocytes play an important role in maintaining extracellular K + homeostasis in the CNS, as well as H + , Cl - , and Ca 2+ homeostassis

Continued research into these mechanisms is essential for developing targeted therapies and enhancing our ability to manage this challenging condition