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Protection against peroxynitrite

The overexpression of CX3CL1, a chemokine associated with the immune infiltration of tumor cells, leads to the downregulation of GPX4, thereby inhibiting the GSH/GPX4 axis (91)

The effect of exercise in animal AKI models is discussed below, with potential mechanisms by which exercise attenuates renal damage being highlighted

10.1016/j.drudis.2022.01.004 34 DumanR

FIGURE 2 AMP-activated protein kinase (AMPK), Sirtuin-1, and peroxisome proliferator-activated receptor- (PPAR) coactivator-1 (PGC-1) in particular, play important roles in mitochondrial biogenesis ( + -dependent deacetylases family member owning deacetylating activity ( + ) levels