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To demonstrate substantial clinical improvement over currently available treatments, we stated that we consider supporting evidence, preferably published peer-reviewed clinical trials, that show improved clinical outcomes, such as reduction in mortality, complications, subsequent interventions, future hospitalizations, recovery time, pain, or a more rapid beneficial resolution of the disease process compared to the standard of care

This technique enables the study of neuronal morphology, synaptic connections, and structural changes over time (Li et al., 2021)

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Vincristine caused a sharp increase in histone 3 phosphorylation at serine 10 (pS10-H3), likely due to its interference with mitotic spindle assembly, causing mitotic arrest ( Supplementary Figure S7A )