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Nucleic acid binding sites are evolved by an analogous procedure to nucleic acid binding proteins except that the starting substrates contain variant binding sites and recombinant forms of these sites are screened as a component of a vector that also encodes a nucleic acid binding protein

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The predominant lung cancer subtype, non-small-cell lung cancer (NSCLC), accounts for 80% of lung cancer-associated deaths, and about 70% of patients have locally advanced or metastatic disease at the time of diagnosis

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