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The binding of the ethacrynic acid-glutathione conjugate shows that the contacts of the glutathione moiety with the protein are identical to those observed in crystal structures of the enzyme with other glutathione-based substrates and inhibitors

Although this practice is common across biomedical research, it has unintended consequence of systematically removing female-specific biological variability from the evidence base

Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, et al

The colloquial term shin splints refers to leg pain that arises from a variety of sources, such as arch strains, tendinitis, compartment syndrome, or stress fractures of the tibia or fibula

Cystine uptake determined the sensitivity of acute myeloid leukemia cells to APR-246 Since cysteine is a biosynthetic precursor of GSH, we asked whether the ability of cells to provide cysteine for GSH synthesis underlies the sensitivity to APR-246