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Landmark trials and large population-based analyses demonstrate that the omission of brachytherapy, even when compensated with modern EBRT dose escalation, results in inferior local control and significantly reduced overall survival [90, 91]

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Under these conditions, BSP-2 yield reached 558.90 8.83 mg/g, representing a 2.7-fold increase over conventional hot water extraction

Our findings demonstrated that A45, but not polyethylene glycol (PEG), elicited significant metabolic perturbations, particularly in amino acid, energy, and redox-related pathways, as well as connections to inflammation- and fibrosis-related phenotypes, consistent with its high fibrogenic potential

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