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Gut microbiota dysbiosis-derived macrophage pyroptosis causes polycystic ovary syndrome via steroidogenesis disturbance and apoptosis of granulosa cells

Ferrostatin 1 (Fer1), a known ferroptosis inhibitor, was used for co-treatment experiment and abrogated RSL3-mediated lipid peroxidation in PTC cells

Lysolecithin (LPC) [Sigma, #62962] was dissolved in 100% sterile methanol to a stock concentration of 50 ng/mL

Similarly, mycotoxin T2 and DON have detrimental effects on neurotransmitter and metabolic activities while ZEN and OTA mycotoxins possess neurotoxicity, hepatotoxicity, and immunotoxin effects

Although we did not investigate each of these cell death pathways, we do not deny their potential roles