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The large amounts of reactive oxygen species (ROS) generated by oxidative stress directly disrupt the redox homeostasis of the ER, leading to protein misfolding and aggregationa core trigger of ERS

Pingili S, Makkena VK, Jaramillo AP, Awosusi BL, Ayyub J, Dabhi KN, et al

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However, several recent studies on the efficacy of minocycline for SCI have produced results that are inconsistent with those of previous promising studies, which adds uncertainty to the future translation and development of this medicine

When cloned and expressed in Escherichia coli , rice tau class GST enzymes showed higher activity toward fluorodifen (a diphenyl ether