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The observed degradant peak was suspected to be hydroxocobalamin and was further confirmed by molecular weight determination

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Neurosci Lett 10:171174 Sonnewald U, Westergaard N, Schousboe A, Svendsen JS, Unsgard G, Petersen SB (1993) Direct demonstration by [13 C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons

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Decreased blood flow to the legs can lead to calf pain when walking, but the study found that glutathione given intravenously twice a day helped ease patient symptoms