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Importantly, dysregulation of lipid, carbohydrate, and iron metabolism are key drivers of prodiabetogenic changes that promote diabetes progression (46,47)

The underlying mechanisms are complex, involving direct and indirect toxic effects, immunologic dysregulation, and oncogenic pathways, primarily driven by oxidative stress, systemic inflammation, insulin resistance, and the presence of numerous carcinogens in tobacco smoke

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Cell Reports, 42 (4), 112388