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Our analysis led to the identification of five genome-wide significant variants, constituting independent loci

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During host cell infection, CoVs trigger an imbalance involving increased ROS production and reduced antioxidant host responses, thereby leading to increased redox stress, reduced antiviral host responses, and increased virus-induced inflammation and apoptosis, ultimately causing cell and tissue damage and end-organ disease 3

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Front Immunol (2013) 4:438