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Efficacy of the classic ketogenic and the modified Atkins diets in refractory childhood epilepsy

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In animal studies, the administration of intermediate NAD + metabolites, such as nicotinamide (NAM), nicotinamide mononucleotide (NMN), or nicotinamide riboside (NR), has been shown to increase NAD + concentrations, which helped improve the health and extend the lifespan of the experimental animals 2,3,4,5,6

Notably, NADPH depletion in SLC7A11 high cancer cells results in disulfide stress accumulation and cytoskeleton remodeling, eliciting disulfidptosis under glucose starvation 28

In addition, HIF-1 increases radioresistance of tumors by enhancing tumor growth through promoting vascularization via upregulation of VEGFs (Fig