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otherwise, it may reduce the affinity and change the conformation of the proteins, preventing the target protein to bind to the residues as expected

90 Modification patterns used in clinical studies or for commercial siRNA Early siRNA therapeutic programs typically employ partial or slight modifications by using 2-OMe, 2-F or PS, 91,92 e.g., alternative 2-OMe modifications were placed in the antisense strand of QPI-1007, whereas just one L-DNA was used in the sense strand

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2.13.21 Christine said: Looks ok for both pregnancy and nursing 2.13.21 Ames said: Hi Doctor