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In all transection models, axons from proximal stump tried to grow towards the distal end through the repair site and led to a bulging at the nerve bridge

However, the evidence for meaningful clinical benefit in elderly populations remains preliminary, and the risk-benefit calculation must account for potential effects on glucose metabolism and cancer risk

G.BadshahH.et al (2016)

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This connection has been previously described alongside functional deficits in the 6-OHDA model of PD (Tuppy et al., 2015