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Under physiological conditions, the activity of Cdk5 is tightly controlled by p35 or p39, which are specific activators of Cdk5 and highly expressed in post-mitotic neurons

Results Autoantibody-induced arthritis sensitizes multiple sensory neuron types before, during and after inflammation We used a cocktail of monoclonal pathogenic antibodies targeting cartilage, similar to RA autoantibodies, to induce arthritis in mice (cartilage autoantibody-induced arthritis model) 18

The development of ME/CFS is closely associated with stressful life events (Theorell et al., 1999

Khan E, Hasan I, Haque ME

Maintain aseptic handling to preserve compound integrity