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The inherent multidrug resistance induced resistance to macrolides and disparities between in vitro drug sensitivity testing and clinical responses all contribute to the complexity of treatment

Additionally, radiation-induced damage is amplified by the generation of reactive oxygen species (ROS), chemically reactive entities capable of oxidizing proteins and lipids and inducing single-strand DNA breaks (indirect effects)

Here it helps to convert propinonyl-CoA to methylmalonyl-CoA

The core chelation site relies on the imidazole ring of histidine and the side chain amino group of lysine to ensure the controlled release of copper ions

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