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Following liver injury there is a 3- to 8-fold increase in the extracellular matrix which is of a high density interstitial type, containing fibril-forming collagens (types 1 and III) as well as fibronectin, hyaluronic acid and proteoglycans

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The BBBs vascular endothelial cells are very closely connected, around 50100 times closer than that of the peripheral micro-vessel endothelial cells resulting in tight intercellular junctions between cerebrovascular endothelial cells [3]

For example, separate calcium and iron supplements