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NNMT is a cytosolic enzyme that is primarily expressed in the liver and catalyzes the transfer of methyl group from the cofactor S-(5-adenosyl)-L-methionine (SAM) to other substrates

On the other hand, those with severe deficiencies may require longer to experience the benefits, as their vitamin stores are significantly depleted

If your doctor suspects you have leukemia, they may do a B12 test before ordering a more complex test, such as a bone marrow biopsy

Practitioners should verify current federal, state, and institutional requirements before implementation, as regulatory guidance may evolve

These may include: Nausea and stomach upset Diarrhea Constipation Injection site redness or swelling Itching Headache Dizziness Blood clots Swelling In rare cases, some people may experience an allergic reaction to vitamin B12, which can cause symptoms such as hives, difficulty breathing, and swelling of the face, lips, tongue, or throat