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Interestingly, SIRT6, another sirtuin member, can deacetylate SKP2 on K73 and K77 to enhance its further phosphorylation S72 and S75 mediated by AKT and CK1, respectively, thus preventing the APC-Cdh1 E3 ubiquitin-ligase-mediated degradation 74,75

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Front Biosci 12:332343 Lalo U, Koh W, Lee CJ, Pankratov Y (2021) The tripartite glutamatergic synapse