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Anakinra, a recombinant IL-1Ra, was verified to improve survival of patients with acute liver injury by regulating inflammatory response (99)

Advanced glycation end-products also activate inflammatory signals through RAGEs on EC macrophages, and smooth muscle cells

The outcomes included C-reactive protein (CRP), tumour necrosis factor- (TNF-), interleukin-6 (IL-6), interleukin-1 beta (IL-1), total antioxidant capacity (TAC), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPX)

For example, PAE not only protects against AS but also exerts neuroprotective effects by inhibiting neuronal ferroptosis in cerebral hemorrhage (Wei et al., 2023)