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This leads to peripheral and hepatic insulin resistance and compensatory intra-portal hyperinsulinemia, which results in increased hepatic GH sensitivity that aggravates the condition further ( Table 1

2015;16(6):e13140

Liver tissues (10 g) were chopped into small pieces on a petri plate on ice and homogenized with 20 ml homogenization buffer A (25 mM HEPES-KOH, pH 7.4, 125 mM potassium acetate, 2.5 mM magnesium acetate, 1 mM DTT) using a Dounce glass homogenizer (50 strokes)

Baseline nL predicted incident stroke