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In elderly patients, the hospitalization rate for infections with vedolizumab or ustekinumab is lower than with anti-TNF, and the overall adverse event rates are similar [338, 339]

(Strong recommendation, high level of evidence) Summary of Evidence Gastrointestinal symptoms alone cannot accurately differentiate CD from other common gastrointestinal disorders (e.g., 2050% of patients with CD fulfilled Rome criteria for irritable bowel syndrome)

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Evidence for penile endothelial dysfunction, CSMC fibrosis, and neural injury in varicocele is derived predominantly from animal models, gene-knockout systems, and extrapolation from broader ED models, including diabetes, vascular injury, aging, and cavernous nerve injury