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Finally, MDSCs can also express immunosuppressive ligands, such as programmed death ligand-1 (PD-L1), which in turn suppresses T-cell priming and activation (151)

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Infection: Although rare, there is a small risk of infection at the injection site

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Our findings suggest that IF may offer a promising non-pharmacological intervention for managing RA in this population, potentially addressing both primary disease symptoms and associated metabolic complications 34

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(Supplementary Figure S8 and Figure 2C)

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