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Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence

doi: 10.1088/1758-5090/adc15 107 AlamMZDevalarajaSHaldarM

Beyond direct ligand-sensing transcription regulators, we do not know of any two-component systems or chemotaxis regulators that sense and respond to carnitine

The BP protein called hydrolysate (enzymatically cleaved BP protein) can have strong anticancer activity by inhibiting human bronchogenic carcinoma (ChaGo-K1 cells), resulting in IC 50 value of 1.37 g/mL (174, 176)