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In order to demonstrate that the 127 gene signature is related to regional emphysema severity within individuals and not to differences between donors and COPD patients or to differences in levels of emphysema between COPD patients, we repeated the same statistical analysis while only including the five COPD patients with emphysema and standardizing the Lm measurements within each patient core to a mean of zero and a standard deviation of one (Z-score)

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The concentration, exposure times, and model design are determined by the researcher based on the studys objectives, prior literature, and institutional guidelines

This is fundamentally different from taking a copper supplement, where free copper ions can accumulate and cause oxidative damage to cells