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[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Ashino T, Sudhahar V, Urao N, Oshikawa J, Chen GF, Wang H, et al

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Long-term use is not recommended because of the risks associated with prolonged exposure to stimulant medications

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The resulting glutamine surplus aggravates glutamine-induced osmotic stress in the cytoplasm, at the same time rendering more glutamine available for (i) its Slc7a6-mediated exchange for extracellular arginine, which increases intra-astrocytic accumulation of reactive nitrogen species (ii) glutamine transport to astrocytic mitochondria, which leads to mitochondrial dysfunction (the Trojan Horse mode of action)