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(Although multiple sclerosis (MS) is classically an autoimmune inflammatory demyelinating disease rather than a primary proteinopathy, we include it here due to overlapping chronic CNS injury and immune dysregulation influenced by the microbiome.) For each disease, specific microbial taxa, metabolites, and pathways implicated in pathogenesis are discussed

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Importantly, host-produced reactive oxygen and nitrogen species (ROS/RNS) are responsible for inducing antibiotic tolerance in a wide range of bacterial species, including S

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