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However, despite their proven effectiveness against foodborne pathogens, the underlying mechanisms of PDD-generated CAP remain limitedly studied (Gonzlez-Gonzlez et al

This limitation has stimulated interest in targeted antiferroptotic approaches that aim to interrupt this pathological cycle and promote tissue repair

Mercury chloride-induced oxidative stress in human erythrocytes and the effect of vitamins C and E in vitro

Although iron-dependent prolyl hydroxylases (PHDs) regulate both isoforms and iron chelation can stabilize HIF-1 and HIF-2 in vitro (74), these observations collectively suggest that the gut may implement additional, tissue-specific mechanisms that bias HIF isoform activity and downstream iron handling