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Am J Respir Cell Mol Biol 39:105112

DNA replication vulnerabilities render ovarian cancer cells sensitive to poly(ADP-ribose) glycohydrolase inhibitors

With the MTHFR mutation, your body cannot appropriately detox and expel this form of vitamin

Early chemoproteomic studies using erastin analogs conjugated to a solid support matrix identified the mitochondrial voltage dependent anion channel 2 and 3 (VDAC2 and VDAC3) as direct erastin targets [13]

11% of patients had a complete response, and 61% of patients had a partial response.[13][Level of evidence C2] At 1 year, 91% of responses were ongoing (95% CI, 72%97%), and 92% of patients were progression-free