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In SOD1 mouse models, endplate denervation was seen prior to clinical weakness and motor neuron loss, suggesting that NMJ compromise occurs early in the pathophysiology of ALS and is often the inciting event prior to lower motor neuron injury (dying back hypothesis) [283]

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Employing Travel Cost to Compare the Use Value of Competing Cultural Organizations

Squire, P., Naude, J., Zentner, A., Bittman, J

In milder or borderline cases, high-dose oral vitamin B12 may be sufficient, depending on absorption and clinical context