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L2-Cmu reduces cancer and improves survival in females In a 6 mo interim intervention trial with L2-Cmu in older mice, we performed an extensive histopathologic analysis and noted a reduction in endometrial hyperplasia severity (Supplementary Fig

It was originally FDA-approved to reduce visceral fat accumulation in HIV patients on antiretroviral therapy, but its increasingly used off-label in metabolically healthy adults with excess abdominal fat

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In ovarian cancer, SIRT1 inhibits the transcriptional activity of HIF-1 through deacetylation, thereby preventing the mesenchymal transformation of ovarian cancer cells 42