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Gut microbiota alterations in CKD CKD is characterized by significant alterations in gut microbiota composition, including an increased abundance of Streptococcaceae , Enterobacteriaceae , and Streptococcus , alongside reduced levels of Prevotellaceae , Prevotella 9 , Prevotella , and Roseburia ( Lachnospiraceae NK4A136 group, Bacteroides , Ruminiclostridium 5 group, Enterobacter , Dorea , and Christensenellaceae ( Escherichia and Hungatella genera and reduced butyrate-producing bacteria ( Citrobacter and Klebsiella genera with decreased Roseburia , highlighting potential targets for therapeutic intervention ( Patients with idiopathic membranous nephropathy exhibit elevated Proteobacteria and reduced Lachnospira , highlighting key gut microbiota alterations ( Firmicutes / Bacteroidetes ratios, coupled with intestinal barrier dysfunction, serve as pathogenic markers ( Escherichia-Shigella expansion, suggesting novel diagnostic and therapeutic targets ( Efforts to elucidate the causal and correlative effects of gut microbiota in CKD have identified distinct microbial species and families rather than overall diversity during low-protein diet interventions ( The unique gut microbiota profile in kidney stone patients suggests that dietary adjustments and personalized therapies, such as synbiotics, may restore eubiosis and prevent stone formation/recurrence ( Lactobacillus species ( L