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P.PumaL

4.3 Reduction of carcinogenic effects of chemical substances Selenium can prevent the metabolic activity of certain chemical carcinogens or antagonize their metabolites thereby inhibiting the carcinogenic effects of chemical carcinogens (138)

In the context of impaired glutathione metabolism, two converging factors promote PGA accumulation

One report of a randomized controlled trial that allocated supplementation with vitamin D to infertile women with PCOS found that supplementation markedly reduced high-sensitivity C-reactive protein (hs-CRP) levels and increased total antioxidant capacity, indicating the potential of vitamin D to mitigate inflammation and oxidative stress in PCOS ( These findings also laid emphasis on how vitamin D influences multiple molecular aspects involved with the pathogenesis of PCOS

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