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Furthermore, in ME/CFS, PEM has been associated with defects in the TCA cycle, where a metabolic impairment reduces ATP production and increases lactate accumulation (Nilsson et al., 2020)

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examined the effects of Oleanolic acid (OA) preconditioning in a rat model of I/R injury (104)

A CS-pectin delivery system has also been developed to encapsulate anthocyanins, protecting them through the gastric environment and ensuring controlled release in the small intestine, thereby improving stability and bioavailability (191)

Overall, these results suggest that although PEP availability could be a limiting factor for the in vivo glucose-PTS activity, L