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FDA staff found inadequate characterisation, no evidence supporting insomnia effectiveness and no clinical safety data

Due to the unique anatomical relationship between the CNS and the nasal cavity, relatively quick along with easy access for nanodrugs to the brain could be realized via intranasal administration

The pineal gland regulates circadian rhythm and produces melatonin, which governs sleep, immune function, and antioxidant defense

The structurally simplified Ang IV peptidemimetic 16 was almost as active as Ang IV as an IRAP inhibitor while 17 was five-fold and 18 and the open chain 19 were 20-fold less active (Figure 5)