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Increased hypersensitivity to lidocaine, other amide local anaesthetics, a history of epileptiform convulsions with lidocaine, severe bradycardia, severe hypotension, cardiogenic shock, severe chronic heart failure (II-III degree), sick sinus syndrome, Wolff-Parkinson-White syndrome, Adams-Stokes syndrome, II and III degree atrioventricular (AV) block, hypovolemia, severe hepatic/renal impairment, porphyria, myasthenia

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A 26-week diabetes study measured human activity at 1 mg, but its endpoint was blood sugar rather than long-term weight. A short outpatient cohort measured about 4.7% weight loss over four weeks at 2.5 mg. Below 1 mg, estimates rely on pharmacokinetics and mechanism