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Takihara Y, Inatani M, Eto K et al (2015) In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

doi: 10.1097/00002030-200311210-00009

Current research extrapolations suggest 1216 week treatment cycles followed by 48 week rest periods, though this is based on precautionary principle rather than evidence of receptor desensitization or tolerance development