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The following data were collected: publication year, country and continent, study setting (e.g., hospital, private practice, academic clinic), sample size, age range, mean age, study design, population characteristics, intervention details, outcomes, and effect measures (e.g., serum B12 levels)

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on the other hand, supplementing with functional folate can mask a B 12 deficiency by normalizing changes to red blood cells that are often an early sign of B 12 deficiency

Most adolescents and adults require 2.4 micrograms per day, while higher levels are recommended for pregnant or breastfeeding women

doi: 10.1002/biof.5520060312, 41