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The content of these sulfur-containing secondary compounds strongly depends on stage of development of the plant, temperature, water availability and the level of nitrogen and sulfur nutrition

The biological effects of bromelain have been partially associated with the modulation of the arachidonic acid cascade (124), similar to another study that showed the alteration of arachidonic acid metabolism with anti-inflammatory and antiplatelet effects of bromelain (135)

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During an eight-year follow-up period, the average incidence of liver cancer was reduced by 35% in the selenium-supplemented population, while no reduction was found in the control populations

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