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[DOI] [PMC free article] [PubMed] [Google Scholar] 179.Dekker E., Tanis P.J., Vleugels J.L.A., Kasi P.M., Wallace M.B

The conceptualization of drug interaction and potential relationship to an individuals ability to break down drugs or metabolism influenced by genetics was raised by Motulsky in 1957 15,16 and later supported by genetic-based pharmacokinetics research