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Under normal physiological conditions, substrates that feed into mitochondrial Complexes I and II (site of CoQ10 binding and activity) produce low levels of ROS that are essential for intracellular signalling 9,11

Proteomic changes in the heart following CKD in diabetes To investigate the molecular pathways differentially regulated in the myocardium of swine with DM and DM_CKD, we performed mass spectrometry-based proteomics on LV samples and detected 3500 proteins (Table S2)

Binding of a metabolite of 3, 4, 3, 4-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin

Razavipour et al., 2022)

The psychological mechanisms involved, including cognitive distortions and maladaptive coping strategies, further complicate the picture, making it essential to consider both the biological and psychological perspectives in this context