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In the context of drug discovery, researchers often use the assay to screen for proteins that interact with small molecules or candidate drugs

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Consequently, the quest for effective and highly selective GLS inhibitors remains an open question

It is typically reversible with dose reduction but should not be ignored

Alternatively, the lack of an apparent role for BNIP3 and NIX may indicate a mitochondrial quality control mechanism in play that is not mitophagy at all